Summary

Overall, DMPD has many advantages over DBS but retains all the benefits.  With the SurePet micropippet, the sample collection procedure is greatly simplified.  This technology is especially suitable to the therapeutic drug monitoring, drug abuse detection, and diagnostics methods currently using DBS.  

  • ​better data quality, no hematocrit effect
  • better sample storage, no cross contamination
  • uniformed replicate samples (6 per cartridge), repunching from a single DBS will give less consistent results
  • low cost per sample comparing to DBS cards
  • easy to operate in analytical labs with no punch and possible automation
  • safety for lab personnel since no direct contact to the biological samples (samples with HIV and other infectious diseases)
  • Compare to the blood liquid microsampling, DMPD retains all the advantages of DBS with storage and stability improvement


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SurePet micropipette is very easy to use.  It delivers the designed volume (5µL or 10 µL) with the following simple steps:

  • Place the pipette tip inside the liquid sample.  Keep the pipette in horizontal position to accelerate the sample collection.  Watch the sample reaches the end of the capillary and stops,









​                      load blood into micropipette                         collect blood from finger to micropipette


  • Place the pipette tip onto a paper disc inside a DMPD cartridge and allow liquid flow from the pipette to the paper disc.  To speed the sample transfer, slightly squease the pipette plastic bulb.










                        spot blood sample onto a paper disc


  • Liquid microsampling with SurePet micropipette.  Exact volume of liquid sample (blood, plasma, serum, urine, tear, sweat, saliva, etc. can be collected and diluted with a known volume of dilution solvent.  The micropipette is acting as a sample transfer tool and the diluted sample keeps liquid format for storage and analysis.










                        Add blood sample to a cryo tube

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SurePet fixed-volume capillary micropipette

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DMPD Cartridges


Dried Matrix on Paper Disc --  A new technology derived from dried blood spot (DBS) by applying matrix sample on a precut paper disc. The paper disc is placed in a plastic cartridge.  Matrix sample is loaded with a pipette (unsaturate method) or a capillary tube (saturate method).  During the sample analysis, the paper disc is removed from the cartridge to an extraction plate using a vacuum tweezer or a funnel.  DMPD employs the concept of whole spot analysis and effectively eliminates variations due to hematocrit or other spreading factors.


DMPD works with all liquid biological matrices such as blood, plasma, urine, CSF, tear, sweat, etc.  The paper disc is protected by the plastic cartridge so inter or intra sample contamination is not possible. 


Liquid samples can be loaded to DMPD by a pipette, a SurePet micropipette, or by a capillary tube (saturate method that does not require an accurate volume measurement since the size of paper disc controls the sample volume, the volumetric absorption microsampling concept we applied first)..  DMPD with saturated sample loading method has been implemented in a clinical study with great matching results to whole blood analysis.

Transfer DMPD with automation


Transfer DMPD sample from a cartridge to an extraction plate is easy.  A simple tool like a vacuum tweezers is great for this purpose.  Here a prototype of automatic transfer machine is shown in the video below.