Overall, DMPD has many advantages over DBS but retains all the benefits. With the SurePet micropippet, the sample collection procedure is greatly simplified. This technology is especially suitable to the therapeutic drug monitoring, drug abuse detection, and diagnostics methods currently using DBS.
SurePet micropipette is very easy to use. It delivers the designed volume (5µL or 10 µL) with the following simple steps:
load blood into micropipette collect blood from finger to micropipette
spot blood sample onto a paper disc
Add blood sample to a cryo tube
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Dried Matrix on Paper Disc -- A new technology derived from dried blood spot (DBS) by applying matrix sample on a precut paper disc. The paper disc is placed in a plastic cartridge. Matrix sample is loaded with a pipette (unsaturate method) or a capillary tube (saturate method). During the sample analysis, the paper disc is removed from the cartridge to an extraction plate using a vacuum tweezer or a funnel. DMPD employs the concept of whole spot analysis and effectively eliminates variations due to hematocrit or other spreading factors.
DMPD works with all liquid biological matrices such as blood, plasma, urine, CSF, tear, sweat, etc. The paper disc is protected by the plastic cartridge so inter or intra sample contamination is not possible.
Liquid samples can be loaded to DMPD by a pipette, a SurePet micropipette, or by a capillary tube (saturate method that does not require an accurate volume measurement since the size of paper disc controls the sample volume, the volumetric absorption microsampling concept we applied first).. DMPD with saturated sample loading method has been implemented in a clinical study with great matching results to whole blood analysis.
Transfer DMPD sample from a cartridge to an extraction plate is easy. A simple tool like a vacuum tweezers is great for this purpose. Here a prototype of automatic transfer machine is shown in the video below.